The gastric mucosal
barrier
The gastric mucosal barrier is a thick, viscous, mucous
material that provides a barrier between the mucosal lining and acidic gastric
secretions. The gastric mucosal barrier maintains the integrity of the gastric
mucosal lining and is a defense against corrosive substances. The two sphincter
muscles—the cardiac, located at the upper portion of the stomach, and the
pyloric, located at the lower portion of the stomach—act as barriers to prevent
reflux of acid into the esophagus and duodenum.
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