Antiulcer agents
Peptic ulcer is a broad term for an ulcer that occurs in
the esophagus, stomach, or duodenum within the upper gastrointestinal (GI)
tract. Ulcers are more specifically named according to the site of involvement:
esophageal, gastric, or duodenal. Duodenal ulcers occur 10 times more
frequently than gastric and esophageal ulcers. The release of hydrochloric acid
(HCl) from the parietal cells of the stomach is influenced by histamine,
gastrin, and acetylcholine. Peptic ulcers occur when there is a hypersecretion
of hydrochloric acid and pepsin, which erode the GI mucosal lining.
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