Pharma gyan Pandit

The phosphate buffer system in the body

The phosphate buffer system is also effective in maintaining physiological pH. At pH 7.4 the HPO₄^-2/H₂PO₄^- ratio is approximately 4:1. In kidney, the pH of urine can drop to 4.5-4.8 corresponding to HPO₄^-2/H2PO₄^- ratio of 1:99- 1:100.