Sunday 17 September 2017

Ratio of Bicarbonate and carbonic acid Buffer System
The normal HCO3-/ H2CO3 ratio is 27/1.35 meq/lt (20:1) corresponding to pH 7.4. In lungs there is reversal of the above process due to the large amount of O2 present. Oxygen combines with the protonated deoxyhemoglobin releasing proton. 

These combine with HCO3- forming H2CO3 which then dissociates to CO2 and water. The carbon dioxide is exhaled by the lungs. Thus by regulating breathing it is possible for the body to exert a partial control on the HCO3-/H2CO3 ratio.

K++HCO3-+HHb+O2--------------àK++HbO2-+H2CO3

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