Ratio of Bicarbonate and
carbonic acid Buffer System
The normal HCO3-/ H2CO3
ratio is 27/1.35 meq/lt (20:1) corresponding to pH 7.4. In lungs there is
reversal of the above process due to the large amount of O2 present.
Oxygen combines with the protonated deoxyhemoglobin releasing proton.
These
combine with HCO3- forming H2CO3
which then dissociates to CO2 and water. The carbon dioxide is
exhaled by the lungs. Thus by regulating breathing it is possible for the body
to exert a partial control on the HCO3-/H2CO3
ratio.
K++HCO3-+HHb+O2--------------àK++HbO2-+H2CO3
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