Deficiency of Vitamin C
Symptoms of vitamin C deficiency (knowns as scurvy) appear
once plasma concentrations of ascorbic acid drop below 10 micromolar (μM), a
level that can be prevented by consuming as little as 10 mg of ascorbic acid
daily. Cutaneous manifestations of scurvy.
Scurvy symptom & Causes: declines in collagen
synthesis, leading to disruption of connective tissue and fragility of blood
vessels. Early symptoms in the skin include a thickening of the stratum corneum
and spots of small subcutaneous bleeding. As scurvy progresses, wound healing
is impaired due to the loss of mature collagen, which allows wounds to remain
open. Skin lesions caused by vitamin C deficiency are remediated by an adequate
intake of vitamin C.
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