Vitamin E Interactions with Drugs
Vitamin E supplements have the potential to interact with
several types of medications.
Anticoagulant and antiplatelets drugs
Vitamin E can inhibit platelet aggregation and antagonize
vitamin K-dependent clotting factors. As a result, taking large doses with
anticoagulant or antiplatelet medications, such as warfarin, can increase the
risk of bleeding, especially in conjunction with low vitamin K intake. The
amounts of supplemental vitamin E needed to produce clinically significant
effects are unknown but probably exceed 400 IU/day.
Simvastatin and niacin
Some people take vitamin E supplements with other
antioxidants, such as vitamin C, selenium, and beta-carotene. This collection
of antioxidant ingredients blunted the rise in high-density lipoprotein (HDL)
cholesterol levels, especially levels of HDL2, the most cardioprotective HDL
component, among people treated with a combination of simvastatin and niacin.
Chemotherapy and radiotherapy
Oncologists generally advise against the use of antioxidant
supplements during cancer chemotherapy or radiotherapy because they might
reduce the effectiveness of these therapies by inhibiting cellular oxidative
damage in cancerous cells. Although a systematic review of randomized
controlled trials has called this concern into question, further research is
needed to evaluate the potential risks and benefits of concurrent antioxidant
supplementation with conventional therapies for cancer.
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