Haemostasis and Fibrinolysis
Hemostasis is the arrest of bleeding
from damaged blood vessels. It is complex cascade of enzymatic reactions.
Natural clotting limitation factors
are heparin and antitrombin IIII Fibrinolysis is lysis of thrombus for
restoration of blood flow:
Pathology of
haemostasis and fibrinolysis: ·
- Decrease in blood coagulation and (or) increase in fibrinolysis causes bleeding.
- Increase in blood coagulation and (or) decrease in fibrinolysis causes thrombosis, thromboembolism, syndrome of desseminated intravasal blood coagulation.
Drugs affecting blood coagulation and fibrinolysis
1. Coagulants (They increase blood coagulation)
2. Anticoagulants (They decrease blood coagulation)
3. Anti-platelet drugs (They decrease platelet aggregation)
4. Fibrinolytic drugs (They increase fibrinolysis)
5. Inhibitors of fibrinolysis (They decrease fibrinolysis)
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