Dissolution Test for tablets
Dissolution is an official
test. Dissolution is performed to check the percentage release from the dosage
forms like tablets. Tablet breaks down into small particle which offers a
greater surface area to the dissolving media. Disintegration test does not give
assurance that particles will release drug in solution at an appropriate rate,
that’s why dissolution tests & it is specifications developed for all
tablet products.
1. USP Dissolution
apparatus I (Basket method)
A single tablet is
placed in a small wire mesh basket attached to the bottom of the shaft
connected to a variable speed motor. The basket is immersed in a dissolution
medium (as specified in monograph) contained in a 1000 ml flask. The flask is
cylindrical with a hemispherical bottom.
The flask is maintained at 37 ± 0.50C
by a constant temperature bath. The motor is adjusted to turn at the specified
speed and sample of the fluid are withdrawn at intervals to determine the
amount of drug in solutions.
USP Dissolution
apparatus II (Paddle method)
It is same as
apparatus-1, except the basket is replaced by a paddle. The dosage form is
allowed to sink to the bottom of the flask before stirring.
For dissolution
test U.S.P. specifies the dissolution test medium and volume, type of apparatus
to be used, rpm of the shaft, time limit of the test and assay procedure for.
The test tolerance is expressed as a % of the labeled amount of drug dissolved
in the time limit.
This comment has been removed by the author.
ReplyDeleteThanks for sharing such a great post, i was looking for this helpful information. I want to get more information about Testing Equipment Supplier
ReplyDelete