Friday 18 November 2016

Dissolution Test for tablets
Dissolution is an official test. Dissolution is performed to check the percentage release from the dosage forms like tablets. Tablet breaks down into small particle which offers a greater surface area to the dissolving media. Disintegration test does not give assurance that particles will release drug in solution at an appropriate rate, that’s why dissolution tests & it is specifications developed for all tablet products.
1. USP Dissolution apparatus I (Basket method)
A single tablet is placed in a small wire mesh basket attached to the bottom of the shaft connected to a variable speed motor. The basket is immersed in a dissolution medium (as specified in monograph) contained in a 1000 ml flask. The flask is cylindrical with a hemispherical bottom. 

The flask is maintained at 37 ± 0.50C by a constant temperature bath. The motor is adjusted to turn at the specified speed and sample of the fluid are withdrawn at intervals to determine the amount of drug in solutions.
USP Dissolution apparatus II (Paddle method)

It is same as apparatus-1, except the basket is replaced by a paddle. The dosage form is allowed to sink to the bottom of the flask before stirring. 

For dissolution test U.S.P. specifies the dissolution test medium and volume, type of apparatus to be used, rpm of the shaft, time limit of the test and assay procedure for. The test tolerance is expressed as a % of the labeled amount of drug dissolved in the time limit. 

2 comments:

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  2. Thanks for sharing such a great post, i was looking for this helpful information. I want to get more information about Testing Equipment Supplier

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