Histamine2 antagonists
H2 antagonists, also called H2
blockers, are a class of medications that block the action of histamine at the
histamine H2 receptors of the parietal cells in the stomach. H2
antagonists can be used in the treatment of dyspepsia, but have been surpassed
by the more effective proton pump inhibitors.
Mechanism: Decreases the effect
histamine has on the H2 receptor sites. When these sites are
stimulated, the parietal cells excrete gastric acid.
Indications:
Prophylactic treatment for stress ulcers and active
gastric/duodenal ulcers
Examples: Cimetidine, Famotidine,
Nizatidine, Ranitidine
Side effects: Headaches, dizziness,
confusion
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