Friday, 2 June 2017

Tablet mottling

Tablet mottling or dark areas. This problem occurs when a drug has different color than the tablet excipients or when a drug has colored degradation products. This problem also caused by intragranular migration of the soluble dye during the drying stage which may give rise to dry granules with a highly colored outer zone and interior. During compaction granules are fractured and the colorless interior is exposed resulting in mottled tablets.

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