Mechanism of Action
of Niraparib (Zejula)
PARP is a family of
proteins involved in many functions in a cell, including DNA repair, gene
expression, cell cycle control, intracellular trafficking and energy
metabolism. PARP proteins play key roles in single strand break repair through
the base excision repair pathway.
PARP inhibitors
have shown activity as a monotherapy against tumors with existing DNA repair
defects, such as BRCA1 and BRCA2, and as a combination therapy when
administered together with anti-cancer agents that induce DNA damage.
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