Pharma gyan Pandit

Pharmacopoeial quality control tests for tablets

British pharmacopoeia

1.       For all tablets:

                                  I.            Content of active ingredients

                                II.            Disintegration

                              III.            Uniformity of content

                              IV.            Labeling. 

2.       Uncoated  tablets:

                                  I.            Disintegration test

                                II.            Uniformity of weight

3.       Effervescent tablet:

                                  I.            Disintegration test

                                II.            Uniformity of weight

4.       Coated tablet:

                                  I.            Disintegration test

                                II.            Uniformity of weight

Indian pharmacopoeia

Uncoated tablet:

1.       Uniformity of container content

2.       Content of active ingredient

3.       Uniformity of weight

4.       Uniformity of content

5.       Disintegration test

Enteric coated tablet:

1. Disintegration test

Dispersible tablet:

1. Uniformity of dispersion
2. Disintegration

Soluble tablet:

1. Disintegration test

Effervescent tablet:

1. Disintegration/ Dissolution / Dispersion test.

United states pharmacopoeia

Physical tests applicable to tablet formulation:

1.       Bulk density / Tapped density of powder

2.       Powder fineness

3.       Loss on drying

4.       Disintegration test

5.       Tablet friability

6.       Dissolution test

7.       Drug release testing

8.       Uniformity of dosage form

9.       Container permeation test

10.   Labeling of inactive ingredients

Evaluation of Tablets

Official and unofficial tests for evaluation of tablets

Official Tests:

1.       Weight variation

2.       Disintegration  

3.       Dissolution

4.       Drug content

Non-Official Tests:

1.       Hardness

2.       friability