Ideal properties of superdisintegrants
Superdisintegrant
is used as an excipient in the tablet formulation, it has to meet certain
criteria other than its swelling properties. The ideal disintegrants should
have following properties:
1.
Poor solubility
2.
Poor gel formation
3.
Good hydration capacity
4.
Good moulding and flow properties
5.
No tendency to form complexes with the drugs
6.
Good mouth feel.
7.
It should also be compatible with the other excipients and have
desirable tableting properties.
Different commonly
used superdisintagrants are:
Modified Starches- Sodium
Carboxymethyl Starch (Chemically treated Potato Starch) i.e. Sodium Starch
Glycolate (Explotab, Primogel). Mechanism of Action: Rapid and extensive
swelling with minimal gelling. Effective Concentration is 4-6%. Above 8%, disintegration times may
actually increase due to gelling and its subsequent viscosity producing
effects.
Cross-linked
polyvinylpyrrolidone- water insoluble and strongly hydrophilic. i.e. crospovidone
(Polyplasdone XL, Kollidon CL) Mechanism of Action: Water wicking, swelling and
possibly some deformation recovery. Effective Concentration is 2-4%.
Modified Cellulose- Internally
cross-linked form of Sodium carboxymethyl cellulose. i.e. Ac-Di-Sol
(Accelerates Dissolution), Nymcel Mechanism of Action: Wicking due to fibrous
structure, swelling with minimal gelling. Effective Concentrations is 1-3%
(Direct Compression) & 2-4% (Wet Granulation).
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